Cystatin C as a potential marker of Acute Kidney Injury in patients after Abdominal Aortic Aneurysms Surgery-preliminary study.
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1
Department of Internal Medicine and Metabolic Diseases, Uppersilesian Medical Center, Medical University of Silesia, Katowice.
2
Department of General and Vascular Surgery , Uppersilesian Medical Center, Medical University of Silesia, Katowice.
Corresponding author
Anna Bekier-Żelawska
Department of Internal Medicine and Metabolic Diseases, Uppersilesian Medical Center, Medical University of Silesia, Katowice., SPSK nr 7 Górnośląskie Centrum Medyczne, Ul. Ziołowa 45/47, 40-635 Katowice-Ochojec, Polska
Ann. Acad. Med. Siles. 2014;68
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ABSTRACT
Introduction:
Management of asymptomatic abdominal aortic aneurysms (AAA) includes an elective surgery. On top of perioperative complications the postoperative acute kidney injury (AKI) appears to be one of the most severe. A rise in serum creatinine (sCr) may be failed to notice in an early stadium of AKI. A higher level of AKI novel biomarker- cystatin C ( CysC) can be detected in serum 24-48 hours earlier than increase of sCr level.
The purpose of this study was to compare CysC and sCr as an indicator of an early phase of AKI in patients after AAA surgery.
Materials and methods:
Study protocol involved patients classified for elective AAA surgery. The ultimate number of patients who fulfilled inclusion criteria was 14. CysC and sCr were measured one day before surgery (day-1) and 12, 24, 48 and 72 hours after surgery. Operative time and aortic clamping time were also recorded.
Results:
There was a tendency for both sCr and CysC to rise, though not significantly. No statistically significant connection was shown between aortic clamping time release and sCr and CysC. Correlation between sCr and serum CysC revealed statistical significance ( p<0,05). No correlation was shown between sCr and CRP as well as CysC and CRP.
Conclusions:
CysC serum level is not superior to sCr level in diagnosis of AKI after AAA surgery.