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Endothelial function/damage markers and NGAL – intraoperative assessment in blood specimens obtained from different sampling sites during open repair of abdominal aortic aneurysm
1
Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland
2
Department of General and Vascular Surgery, Angiology and Phlebology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
3
Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
Corresponding author
Jan Duława
Klinika Chorób Wewnętrznych i Metabolicznych, Śląski Uniwersytet Medyczny w Katowicach, ul. Ziołowa 45-47, 40-635 Katowice
Klinika Chorób Wewnętrznych i Metabolicznych, Śląski Uniwersytet Medyczny w Katowicach, ul. Ziołowa 45-47, 40-635 Katowice
Ann. Acad. Med. Siles. 2025;79:45-55
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The aim of the study was to investigate the dynamics of changes in the concentrations of neutrophil gelatinase-associated lipocalin (NGAL), an acute kidney injury biomarker, as well as endothelial function/damage markers including P-selectin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and the von Willebrand factor (vWf) in blood specimens obtained from different sampling sites during open abdominal aortic aneurysm (AAA) repair.
Material and methods:
Thirty-three patients qualified for elective open repair (ORe) were enrolled in the study. All the mentioned parameters were determined in blood samples drawn from: 1) the cubital vein prior to surgery, and then intraoperatively, 2) the renal vein before aortic cross-clamping, 3) renal vein immediately before aortic cross-clamp removal, 4) cubital vein immediately before aortic cross-clamp removal, 5) inferior vena cava immediately before aortic cross-clamp removal, 6) renal vein at 5 minutes after aortic cross-clamp removal and 7) cubital vein at 5 minutes after aortic cross-clamp removal.
Results:
The P-selectin, ICAM-1 and VCAM-1 concentrations were found to have decreased in the cubital samples drawn immediately before aortic clamp removal and at 5 minutes after aortic clamp removal vs the pre-surgery cubital samples. Rapid changes during surgery were also found in the NGAL, vWf and VCAM-1 concentrations.
Conclusions:
The obtained results seem to evidence the development of an inflammatory response while open AAA repair is still in progress.
The aim of the study was to investigate the dynamics of changes in the concentrations of neutrophil gelatinase-associated lipocalin (NGAL), an acute kidney injury biomarker, as well as endothelial function/damage markers including P-selectin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and the von Willebrand factor (vWf) in blood specimens obtained from different sampling sites during open abdominal aortic aneurysm (AAA) repair.
Material and methods:
Thirty-three patients qualified for elective open repair (ORe) were enrolled in the study. All the mentioned parameters were determined in blood samples drawn from: 1) the cubital vein prior to surgery, and then intraoperatively, 2) the renal vein before aortic cross-clamping, 3) renal vein immediately before aortic cross-clamp removal, 4) cubital vein immediately before aortic cross-clamp removal, 5) inferior vena cava immediately before aortic cross-clamp removal, 6) renal vein at 5 minutes after aortic cross-clamp removal and 7) cubital vein at 5 minutes after aortic cross-clamp removal.
Results:
The P-selectin, ICAM-1 and VCAM-1 concentrations were found to have decreased in the cubital samples drawn immediately before aortic clamp removal and at 5 minutes after aortic clamp removal vs the pre-surgery cubital samples. Rapid changes during surgery were also found in the NGAL, vWf and VCAM-1 concentrations.
Conclusions:
The obtained results seem to evidence the development of an inflammatory response while open AAA repair is still in progress.
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