Wound healing – characteristics of the ideal dressing
More details
Hide details
1
Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland
2
Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland
3
Students’ Research Club at the Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland
Corresponding author
Paweł Olczyk
Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland, Kasztanowa 3, 41-200 Sosnowiec
Ann. Acad. Med. Siles. 2023;77:197-203
KEYWORDS
TOPICS
ABSTRACT
Wound healing is a dynamic process aimed at restoring homeostasis and functionality of damaged tissue. It is a highly complex, multi-stage process, the disruption of which leads to complications and health problems for the injured person. The discussed process takes place in the human system in two ways. The first of them is granulation and the second is healing per primary. Regardless of the method of wound healing, the individual phases of this process overlap each other, where before the end of the previous phase, the next begins. Demarcation of individual phases is purely practical. There are four phases of healing: the hemostasis phase, the inflammation phase, the proliferative phase – in other words the replication and synthesis phase – and the remodeling phase.
The process of wound healing is a natural, long-term, and complex process that occurs in the body when injured. Incorrect healing may result in chronic wounds, necrosis or excessive scarring. Wound treatment supports this naturally occurring process in the body. In cases that require such support dressings are used, which are an essential element applicable in health care. An ideal dressing should create a barrier against external factors, maintain an appropriate environment in the wound bed (appropriate temperature, optimal humidity, slightly acidic pH, gas exchange), absorb excess of blood and exudate, keep the wound clean – cleanse it of necrotic tissue and toxins – do not adhere to the wound to avoid wound damage during dressing replacement, do not show sensitizing or irritating effects.
REFERENCES (33)
1.
Fornalski J. Wound healing with hypertrophic scars – treatment metods. [Article in Polish]. Nowa Med. 2006; 4: 66–70.
2.
Witmanowski H., Lewandowicz E., Zieliński T., Łuczkowska M., Kruk-Jeromin J. Hypertrophic scars and keloids Part I. Pathogenesis and pathomechanism. [Article in Polish]. Adv. Dermatol. Allergol./Post. Dermatol. Alergol. 2008; 25(3): 107–115.
3.
Jachowicz R. Farmacja praktyczna. Wyd. Lekarskie PZWL. Warszawa 2016.
4.
Olczyk P., Mencner Ł., Komosinska-Vassev K. The role of the extracellular matrix components in cutaneous wound healing. Biomed. Res. Int. 2014; 2014: 747584, doi: 10.1155/2014/747584.
5.
de Mendonça R.J., Coutinho-Netto J. Cellular aspects of wound healing. An. Bras. Dermatol. 2009; 84(3): 257–262, doi: 10.1590/s0365-05962009000300007.
6.
Werner S., Grose R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 2003; 83(3): 835–870, doi: 10.1152/physrev.2003.83.3.835.
7.
Pikuła M., Langa P., Kosikowska P., Trzonkowski P. Komórki macierzyste i czynniki wzrostu w gojeniu ran. Postepy Hig. Med. Dosw. 2015; 69: 874–885, doi: 10.5604/17322693.1162989.
8.
Werner S., Krieg T., Smola H. Keratinocyte–fibroblast interactions in wound healing. J. Invest. Dermatol. 2007; 127(5): 998–1008, doi: 10.1038/sj.jid.5700786.
9.
Wilemska-Kucharzewska K., Bednarczyk M., Rojczyk E., Pałasz A., Kucharzewski M. Rola cytokin w procesie gojenia ran. Leczenie Ran 2015; 12(2): 41–47.
10.
Ghatak S., Maytin E.V., Mack J.A., Hascall V.C., Atanelishvili I., Moreno Rodriguez R. et al. Roles of proteoglycans and glycosaminoglycans in wound healing and fibrosis. Int. J. Cell Biol. 2015; 2015: 834893, doi: 10.1155/2015/834893.
11.
Kotschy M., Kotschy D., Witkiewicz W. The role of tissue factor and tissue factor pathway inhibitor in blood coagulation and in thrombotic complications. Kardiol. Pol. 2010; 68(10): 1158–1162.
12.
Staniszewska M., Słuczanowska-Głąbowska S., Drukała J. Stem cells and skin regeneration. Folia Histochem. Cytobiol. 2011; 49(3): 375–380, doi: 10.5603/fhc.2011.0053.
13.
Braddock M. The transcription factor Egr-1: a potential drug in wound healing and tissue repair. Ann. Med. 2001; 33(5): 313–318, doi: 10.3109/07853890109002083.
14.
Marciniak A., Grześk G., Koziński M., Grześk E., Kubica J. Zmienność dobowa w układzie hemostazy. Folia Cardiol. Excerpta 2010; 5(1): 1–7.
15.
Dembińska-Kieć A., Naskalski J.W., Solnica B. Diagnostyka laboratoryjna z elementami biochemii klinicznej. Edra Urban & Partner. Wrocław 2017.
16.
Sinno H., Prakash S. Complements and the wound healing cascade: an updated review. Plast. Surg. Int. 2013; 2013: 146764, doi: 10.1155/2013/146764.
17.
Velnar T., Bailey T., Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. J. Int. Med. Res. 2009; 37(5): 1528–1542, doi: 10.1177/147323000903700531.
18.
Sundy J.S., Haynes B.F. Cytokines and adhesion molecules in the pathogenesis of vasculitis. Curr. Rheumatol. Rep. 2000; 2(5): 402–410, doi: 10.1007/s11926-000-0040-8.
19.
Gantwerker E.A., Hom D.B. Skin: histology and physiology of wound healing. Facial Plast. Surg. Clin. North Am. 2011; 19(3): 441–453, doi: 10.1016/j.fsc.2011.06.009.
20.
Li J., Chen J., Kirsner R. Pathophysiology of acute wound healing. Clin. Dermatol. 2007; 25(1): 9–18, doi: 10.1016/j.clindermatol.2006.09.007.
21.
Bielefeld K.A., Amini-Nik S., Alman B.A. Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell. Mol. Life Sci. 2013; 70(12): 2059–2081, doi: 10.1007/s00018-012-1152-9.
22.
Rodrigues M., Kosaric N., Bonham C.A., Gurtner G.C. Wound healing: a cellular perspective. Physiol. Rev. 2019; 99(1): 665–706, doi: 10.1152/physrev.00067.2017.
23.
Liekens S., De Clercq E., Neyts J. Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 2001; 61(3): 253–270, doi: 10.1016/S0006-2952(00)00529-3.
24.
Belperio J.A., Keane M.P., Arenberg D.A., Addison C.L., Ehlert J.E., Burdick M.D. et al. CXC chemokines in angiogenesis. J. Leukoc. Biol. 2000; 68(1): 1–8, doi: 10.1189/jlb.68.1.1.
25.
Broughton G. 2nd, Janis J.E., Attinger C.E. The basic science of wound healing. Plast. Reconstr. Surg. 2006; 117(7 Suppl): 12S–34S, doi: 10.1097/01.prs.0000225430.42531.c2.
26.
Podstawy pielęgniarstwa chirurgicznego. E. Walewska [ed.]. Wyd. Lekarskie PZWL. Warszawa 2012.
27.
Artem Ataide J., Caramori Cefali L., Machado Croisfelt F., Arruda Martins Shimojo A., Oliveira-Nascimento L., Gava Mazzola P. Natural actives for wound healing: A review. Phytother. Res. 2018; 32(9): 1664–1674, doi: 10.1002/ptr.6102.
28.
Manowska M. The role of specialist dressing in the local treatment of second-degree burn wound on the leg – case report. Forum Leczenia Ran 2021; 2(3): 135–138, doi: 10.15374/FLR2021017.
29.
Finnerty C.C., Jeschke M.G., Branski L.K., Barret J.P., Dziewulski P., Herndon D.N. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet 2016; 388(10052): 1427–1436, doi: 10.1016/S0140-6736(16)31406-4.
30.
Kozłowska E., Cierzniakowska K., Szewczyk M.T. Postępowanie miejscowe w oparzeniach. Chir. Dypl. 2019; 3: 1–3 [online]
https://podyplomie.pl/chirurgi... [acces-sed on 13 October 2023].
31.
Olczyk P., Komosinska-Vassev K., Krzyminiewski R., Kasperczyk J., Ramos P., Dobosz B. et al. The estimation of blood paramagnetic center changes during burns management with biodegradable propolis-nanofiber dressing. Oxid. Med. Cell. Longev. 2020; 2020: 3675603, doi: 10.1155/2020/3675603.
32.
Komosinska-Vassev K., Olczyk P., Kasperczyk J., Pilawa B., Krzyminiewski R., Dobosz B. et al. EPR spectroscopic examination of different types of paramagnetic centers in the blood in the course of burn healing. Oxid. Med. Cell. Longev. 2019; 2019: 7506274, doi: 10.1155/2019/7506274.
33.
Shi C., Wang C., Liu H., Li Q., Li R., Zhang Y. et al. Selection of appropriate wound dressing for various wounds. Front. Bioeng. Biotechnol. 2020; 8: 182, doi: 10.3389/fbioe.2020.00182.