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2015 vol. 69
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Anti-inflammatory microglial cell function in the light of the latest scientific research
Krzysztof Łabuzek 1
,
 
Edyta Skrudlik 1
,
 
Bożena Gabryel 1
,
 
Bogusław Okopień 1
 
 
 
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Katedra Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach
 
 
Corresponding author
Krzysztof Łabuzek   

Katedra Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach, ul. Medyków 18, 40-752 Katowice, tel. +48 503 067 376
 
 
Ann. Acad. Med. Siles. 2015;69:99-110
DOI: https://doi.org/10.18794/aams/32608
 
 
Article (PDF)
References (53) Citations (4)
 
KEYWORDS
microglia
fractalkine
alternative activation
CD200
IL-1
IL-6
TNF
TGF
 
TOPICS
Medical Biology
Physiology
Histology
 
ABSTRACT
Microglia represent the immune system in the central nervous system. They have long been regarded as as the main aggressor, which induce and support inflammatory and neurodegenerative processes in the central nervous system. The latest studies indicate that they can also play a protective role. In this study we present evidence underlying their anti-inflammatory properties. Microglia can be activated in two different ways and they have two different phenotypes: classical – pro-inflammatory and alternative – anti-inflammatory. The latter is characterized by CD200 expression and fractalkine. Alternatively, the activated microglia also produce pro-inflammatory cytokine. Their influence on the surrounding cells is associated not only with destruction but also with neuroregeneration and myelination. Perhaps the latest reports will draw researchers' attention to new solutions which may be used in the prevention and treatment of the central nervous system diseases through the anti-inflammatory properties of cells which are still seen as inflammatory cells.
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