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ABSTRACT
Group A beta-hemolytic streptococci (Streptococcus pyogenesS. pyogenes) are the etiological factor of a wide range of infections, primarily pharyngitis, inflammation of the skin and subcutaneous tissue, as well as invasive infections. They can also lead to immunological complications, such as acute glomerulonephritis, rheumatic fever, and rheumatic heart disease. Although S. pyogenes may be the etiological factor for sepsis, sepsis of this etiology is rarely observed as a complication of upper respiratory tract infections in clinical practice. The aim of this paper is to present a case report of a 32-year-old man, previously untreated for chronic diseases, who was hospitalized for sepsis caused by S. pyogenes, which was a complication of an upper respiratory tract infection. As a result of targeted treatment with benzyl penicillin, significant improvement in the clinical condition of the patient and normalization of the inflammatory parameters were achieved. Due to a significant increase in the cardiac troponin serum concentration during hospitalization, the diagnostics were extended to include evaluation of the cardiovascular system.
REFERENCES (21)
1.
Huerta L.E., Rice T.W. Pathologic difference between sepsis and bloodstream infections. J. Appl. Lab. Med. 2019; 3(4): 654–663, doi: 10.1373/jalm.2018.026245.
 
2.
Kellum J.A., Formeck C.L., Kernan K.F., Gómez H., Carcillo J.A. Subtypes and mimics of sepsis. Crit. Care Clin. 2022; 38(2): 195–211, doi: 10.1016/j.ccc.2021.11.013.
 
3.
Grondman I., Pirvu A., Riza A., Ioana M., Netea M.G. Biomarkers of inflammation and the etiology of sepsis. Biochem. Soc. Trans. 2020; 48(1): 1–14, doi: 10.1042/BST20190029.
 
4.
Abushaheen M.A., Muzaheed, Fatani A.J., Alosaimi M., Mansy W., George M. et al. Antimicrobial resistance, mechanisms and its clinical significance. Dis. Mon. 2020; 66(6): 100971, doi: 10.1016/j.disamonth.2020.100971.
 
5.
van den Berg M., van Beuningen F.E., Ter Maaten J.C., Bouma H.R. Hospital-related costs of sepsis around the world: A systematic review exploring the economic burden of sepsis. J. Crit. Care 2022; 71: 154096, doi: 10.1016/j.jcrc.2022.154096.
 
6.
Zaccone V., Tosoni A., Passaro G., Vallone C.V., Impagnatiello M., Li Puma D.D. et al. Sepsis in internal medicine wards: current knowledge, uncertainties and new approaches for management optimization. Ann. Med. 2017; 49(7): 582–592, doi: 10.1080/07853890.2017.1332776.
 
7.
Wang J., Ma C., Li M., Gao X., Wu H., Dong W. et al. Streptococcus pyogenes: pathogenesis and the current status of vaccines. Vaccines (Basel) 2023; 11(9): 1510, doi: 10.3390/vaccines11091510.
 
8.
Valderrama J.A., Riestra A.M., Gao N.J., LaRock C.N., Gupta N., Ali S.R. et al. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat. Microbiol. 2017; 2(10): 1425–1434, doi: 10.1038/s41564-017-0005-6.
 
9.
Blöchl C., Holzner C., Luciano M., Bauer R., Horejs-Hoeck J., Eckhard U. et al. Proteolytic profiling of streptococcal pyrogenic exotoxin B (SpeB) by complementary HPLC-MS approaches. Int. J. Mol. Sci. 2021; 23(1): 412, doi: 10.3390/ijms23010412.
 
10.
Jain M., Teçza M., Kagawa T.F., Cooney J.C. Exosite binding modulates the specificity of the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. Comput. Struct. Biotechnol. J. 2022; 20: 4860–4869, doi: 10.1016/j.csbj.2022.08.018.
 
11.
Bryant A.E., Bayer C.R., Chen R.Y., Guth P.H., Wallace R.J., Stevens D.L. Vascular dysfunction and ischemic destruction of tissue in Streptococcus pyogenes infection: the role of streptolysin O-induced platelet/neutrophil complexes. J. Infect. Dis. 2005; 192(6): 1014–1022, doi: 10.1086/432729.
 
12.
Kurupati P., Turner C.E., Tziona I., Lawrenson R.A., Alam F.M., Nohadani M. et al. Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract. Mol. Microbiol. 2010; 76(6): 1387–1397, doi: 10.1111/j.1365-2958.2010.07065.x.
 
13.
Catton E.A., Bonsor D.A., Herrera C., Stålhammar-Carlemalm M., Lyndin M., Turner C.E. et al. Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis. Nat. Commun. 2023; 14(1): 2275, doi: 10.1038/s41467-023-37732-1.
 
14.
Chadha A., Jamal W., Aziz A.R.A., Rotimi V.O. Overwhelming Streptococcus pyogenes sepsis in an elderly patient with septic arthritis. J. Infect. Public Health 2018; 11(3): 434–435, doi: 10.1016/j.jiph.2017.08.011.
 
15.
Holt M., Zerden M. Adolescent primary genital herpes simplex virus type 1 infection with sepsis secondary to Streptococcus pyogenes bacteremia. J. Pediatr. Adolesc. Gynecol. 2022; 35(1): 91–93, doi: 10.1016/j.jpag.2021.07.001.
 
16.
Szczypa K., Wilemska J., Hryniewicz W., Sitkiewicz I. Epidemiology of Streptococcus pyogenes infections, clonal structure population and antibiotic resistance. [Article in Polish]. Post. Mikrobiol. 2013; 52(3): 223–232.
 
17.
Walker M.J., Barnett T.C., McArthur J.D., Cole J.N., Gillen C.M., Henningham A. et al. Disease manifestations and pathogenic mechanisms of Group A Streptococcus. Clin. Microbiol. Rev. 2014; 27(2): 264–301, doi: 10.1128/CMR.00101-13.
 
18.
Smeesters P.R., de Crombrugghe G., Tsoi S.K., Leclercq C., Baker C., Osowicki J. et al. Global Streptococcus pyogenes strain diversity, disease associations, and implications for vaccine development: a systematic review. Lancet Microbe 2024; 5(2): e181–e193, doi: 10.1016/S2666-5247(23)00318-X.
 
19.
Jakubiak G.K. Cardiac troponin serum concentration measurement is useful not only in the diagnosis of acute cardiovascular events. J. Pers. Med. 2024; 14(3): 230, doi: 10.3390/jpm14030230.
 
20.
Carapetis J.R., Steer A.C., Mulholland E.K., Weber M. The global burden of group A streptococcal diseases. Lancet Infect. Dis. 2005; 5(11): 685–694, doi: 10.1016/S1473-3099(05)70267-X.
 
21.
Stec M., Suleja A., Kuczmik W., Mroskowiak A., Migacz M., Holecki M. Comparison of course of infections and antibiotherapy in patients with and without diabetes mellitus – one center experience. Ann. Acad. Med. Siles. 2023; 77: 217–225, doi: 10.18794/aams/166423.
 
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