Madelung disease (MD) is a rare condition characterized by numerous subcutaneous lipomas, also known in the literature as multiple symmetric lipomatosis, benign symmetric adenolipomatosis, or Launois–Bensaude syndrome. MD is little known among physicians, which makes its diagnosis difficult despite the characteristic phenotype of people affected by the disease. Although the treatment options are limited to surgical removal, prompt diagnosis and management improve patients’ quality of life. The purpose of this paper is to present the case report of a 56-year-old patient admitted to our clinic for elective diagnostics of nodular subcutaneous changes in the head, neck, chest, and abdomen. During routine diagnostics, malignancy was ruled out and MD was diagnosed.