Mitral annular disjunction (MAD) is a structural anomaly of the heart characterized by the displacement of the posterior mitral leaflet’s attachment toward the left atrial wall. MAD can lead to mitral valve prolapse, ventricular arrhythmia, and sudden cardiac death. In the general population, MAD can be found in 7%–9% of individuals. Transthoracic echocardiography is the primary imaging assay for detecting MAD, while cardiac magnetic resonance imaging remains the gold standard. The treatment strategy depends on the severity of mitral regurgitation, the presence of symptoms, and the risk of arrhythmia. Further research is necessary to better characterize this condition and to define optimal diagnostic and therapeutic strategies.