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The influence of aging of autonomic system on the course of most common cardiovascular diseases
1
II Katedra i Oddział Kliniczny Kardiologii Szpitala Specjalistycznego w Zabrzu SUM w Katowicach
Corresponding author
Agnieszka Jabłeka
II Katedra i Oddział Kliniczny Kardiologii Szpitala Specjalistycznego w Zabrzu SUM w Katowicach, 41-800 Zabrze, ul. Curie -Skłodowskiej 10, tel. 032 271 10 10, 271 64 71 wew. 72
II Katedra i Oddział Kliniczny Kardiologii Szpitala Specjalistycznego w Zabrzu SUM w Katowicach, 41-800 Zabrze, ul. Curie -Skłodowskiej 10, tel. 032 271 10 10, 271 64 71 wew. 72
Ann. Acad. Med. Siles. 2009;63:60-66
KEYWORDS
ABSTRACT
Aging of autonomic system concerns both sympathetic and parasympathetic part. The process contains structural changes of the neuronal body and terminations and changes of the expression of membrane and intracellular proteins and results in decrease of neural plasticity and regeneration of neurons of autonomic ganglions. Superiority of sympathetic over parasympathetic system is observed in the range of chronotropic regulation of sinus and baroreceptor reflex. The mechanisms attributed to aging modulate pathophysiological processes in which autonomic system plays an important role. Increased sympathetic activation is observed in chronic heart insufficienty which is associated with the increase of the sudden death risk. Activation of autonomic system play also essential role in the pathogenesis of hypertension, atrial fi brillation and
orthostatic hypotony. Dysfunction of autonomic system worsens the quality of life in elderly.
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