The aim of this study is to collect the most important information concerning OA, from the general practitioner's point of view, to guide the patient in the initial diagnosis, cooperate with doctors in other areas, assist in the therapeutic process, and provide medical support in the case of a lack of access to a consulting specialist or a long period of waiting for the consultation. The paper presents the definition of OA, pathological mechanism of its formation as well as forms depending on the aetiology. The symptoms of the disease with particular emphasis on the location and theprinciples of diagnostic and therapeutic procedures in the daily practice of the general practitioner are presented. The important role of rehabilitation in order to improve the quality of life of patients is also highlighted. Osteoarthritis is a progressive, irreversible disease, leading to deterioration of the quality of life of the patient. Applying treatment is not able to stop disease progression, but it is able to slow the development and improve the quality of life of patients. The study highlights the important role of the general practitioner as a guide to the health care system for patients with OA.