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Chronic lymphocytic leukemia coexisting with polycythemia vera in a 67-year-old man: A case report
1
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
2
Oddział Hematologii, Szpital Specjalistyczny Nr 1 w Bytomiu / Ward of Hematology,
Specialist Hospital No. 1 in Bytom, Poland
Corresponding author
Ann. Acad. Med. Siles. 2026;80:104-108
KEYWORDS
TOPICS
ABSTRACT
Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by the absence of the Philadelphia chromosome, increased hemoglobin concentration, and increased erythrocyte mass in peripheral blood. Chronic lymphocytic leukemia (CLL) is a lymphoproliferative neoplasm characterized by the chronic presence in the peripheral blood of a population of clonal B lymphocytes with a typical immunophenotype, usually accompanied by an invasion of the lymph nodes, spleen, and bone marrow. The purpose of this paper is to present a case report of a 67-year-old man diagnosed with PV with coexisting CLL. The patient was admitted to the Ward of Hematology for planned diagnostic workup for polycythemia. The presence of the V617F mutation of the JAK2 gene was confirmed. Due to the elevated lymphocytosis, the diagnostic workup was expanded to include immunophenotyping of the peripheral blood cells, which revealed the presence of a clone with an immunophenotype typical of CLL. Histopathological examination of the bone marrow, including immunohistochemical staining, confirmed PV with concomitant CLL infiltration.
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