Pharmacodynamic drug-drug interactions in the intensive care unit – single-center experience and literature review
Piotr Łój 1  
,   Łukasz Krzych 1  
,   Weronika Ślęzak 2  
,   Aleksandra Olender 2
 
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1
Katedra i Klinika Anestezjologii i Intensywnej Terapii, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach
2
Studenckie Koło Naukowe, Katedra i Klinika Anestezjologii i Intensywnej Terapii, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach
CORRESPONDING AUTHOR
Piotr Łój   

Katedra i Klinika Anestezjologii i Intensywnej Terapii, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, ul. Medyków 14, 40-752 Katowice
 
Ann. Acad. Med. Siles. 2018;72:53–61
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Drug-drug interactions (DDIs) constitute a serious health hazard in everyday clinical practice in the intensive care unit (ICU) setting. DDIs can be divided into pharmacokinetic and pharmacodynamic. We sought to investigate the quantity and quality of possible pharmacodynamic DDIs, and their possible side effects in ICU patients over a 12-month period.

Material and methods:
This retrospective study covered data on the pharmacological treatment of 43 consecutive patients (11 F, 32 M) aged 62 ± 15 years, hospitalized between 01.2015 and 02.2016 in a mixed ICU. Pharmacokinetic DDIs were identified and graded. Only severe and clinically important DDIs were subjected to further analysis.

Results:
The median baseline SAPS III was 53 (IQR 38–67) points. The median ICU stay was 12 (6–25) days. The subjects were treated with a median number of 22 (12–27) drugs. We identified 27 (16–41) possible DDIs per patient, including 3 (1–7) DDI of a severe grade. The total number of severe and clinically important pharmacodynamic pDDIs was 1189 and 320 of them were analyzed in details. Despite the gross number of those life-threatening conditions identified, no clinical sequelae of DDIs were recognized.

Conclusions:
DDIs as well as their effects are challenging for precise evaluation, especially due to the need for multidrug treatment in ICU patients. Despite the gross number of pDDIs in the ICU setting, further investigations are needed to examine their clinical sequelae.

 
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