The news about the infl uence of melatonin on pathogenesis and therapy of breast cancer
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Katedra i Klinika Chorób Wewnętrznych i Chemioterapii Onkologicznej Śląskiego Uniwersytetu Medycznego w Katowicach
Kinga Grabińska   

Katedra i Klinika Chorób Wewnętrznych i Chemioterapii Onkologicznej Śląskiego Uniwersytetu Medycznego w KatowicachKatowice, ul. Ligocka 5/16, tel. +48 694 159 122, +48 505 597 250
Ann. Acad. Med. Siles. 2010;64:58–70
The main role of melatonin is regulation of circadian and seasonal rhythm. Recently there were carried out a lot of researches on the role and potential application of melatonin in prevention and therapy of various diseases. This work is related to researches about the melatonin infl uence on estrogen-dependent breast cancer and application in treating this neoplasm. Probable oncostatic mechanisms i.e. melatonin acting as SERM, SEEM and its infl uence on the hypothalamic – pituitary – reproductive axis, was analyzed. Moreover the relation between circadian disruptions and increase in breast cancer risk were observed. The aim of this work is to show mechanisms melatonin acting and how we can use this hormone in oncology.
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