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The role of pituitary and extrapituitary prolactin in reproduction and oncology
1
Katedra i Klinika Ginekologii i Położnictwa Śląskiego Uniwersytetu Medycznego w Katowicach
2
Klinika Endokrynologii Ginekologicznej Śląskiego Uniwersytetu Medycznego w Katowicach
Corresponding author
Władysław Skałba
Katedra i Klinika Ginekologii i Położnictwa SUM w Katowicach, ul. Medyków 14, tel. +48 696 460 716
Katedra i Klinika Ginekologii i Położnictwa SUM w Katowicach, ul. Medyków 14, tel. +48 696 460 716
Ann. Acad. Med. Siles. 2016;70:46-50
KEYWORDS
TOPICS
ABSTRACT
Prolactin (PRL) acts in the body as a hormone secreted into the blood and as a cytokine. In this review after a brief presentation of the structure of PRL and its receptor, we have focused on local hormone secretion by endometrial and ovarian cancer cells. We have discussed the available information about the autocrine/paracrine hormone signaling pathway in the endometrium and ovary. More attention was focused on the role of PRL in endometrial and ovarian cancers. What is more, the clinical aspects related to the diagnosis and new therapeutic options in these tumors are described. At the end, we have included the suggestion that a number of interesting and important problems of both cancers concerning the pathology and treatment have not yet been discovered, which is a challenge for future research.
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