The role of VEGF-A and its receptors in angiogenesis
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1
Śląski Uniwersytet Medyczny
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Śląski Uniwersytet Medyczny w Katowicach
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Wojewódzki Szpital Specjalistyczny nr 5 im. Św. Barbary w Sosnowcu
Ann. Acad. Med. Siles. 2014;68
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ABSTRACT
Angiogenesis is essential for the proper development of the organism and repair processes, but also significant in cancer progression and metastasis in solid tumors. A major cytokine, that promotes the development of new blood vessels is the vascular endothelial growth factor - VEGF, whereas its the soluble receptors (sVEGF-R1 and sVEGF-R2) have an antiangiogenic activity because they capture and neutralize free molecules of VEGF-A