Concomitance of psoriasis with systemic metabolic diseases – an interdisciplinary problem

BENIAMIN OSKAR GRABAREK; ANNA MICHALSKA-BAŃKOWSKA; JAKUB KRZACZYŃSKI; DOMINIKA WCISŁO-DZIADECKA

doi:10.18794/aams/105477

2019 vol. 73

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Concomitance of psoriasis with systemic metabolic diseases – an interdisciplinary problem

BENIAMIN OSKAR GRABAREK ^1,2,3

ANNA MICHALSKA-BAŃKOWSKA ⁴

JAKUB KRZACZYŃSKI ³

DOMINIKA WCISŁO-DZIADECKA ⁵

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Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, Zabrze, Poland

Center of Oncology, M. Skłodowska-Curie Memorial Institute, Cracow Branch, Poland

Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland

Children’s Dermatology Department, Pediatrics Center John Paul II in Sosnowiec, Poland

Department of Cosmetology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland

Corresponding author

BENIAMIN OSKAR GRABAREK

Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology, ul. Park Hutniczy 3–5, 41-800 Zabrze, Poland, Center of Oncology, M. Skłodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Kraków, Poland, Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jedności 8, 41-200 Sosnowiec

Ann. Acad. Med. Siles. 2019;73:236-242

DOI: https://doi.org/10.18794/aams/105477

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ABSTRACT

Introduction:
The aim of this study was to assess how often psoriasis co-occurs with diabetes, hypertension, and metabolic syndrome. The intention of the authors is to draw the attention of general practitioners, to the complex clinical picture of psoriasis, the implications of internist diseases, and thus the need to provide patients with interdisciplinary care.

Material and methods:
A survey on the prevalence of metabolic systemic comorbidities with psoriasis was performed on a group of 32 patients diagnosed with common psoriasis (20 men and 12 women). The characteristics of the study group are as follows (mean ± standard deviation): age 53.9 ± 10.4 years, height 169.9 ± 1.5 cm, body weight 88.8 ± 21.5 kg, BMI 30.65 ± 6.18, waist circumference 108.34 ± 17.14 cm.

Results:
Of the 32 patients with psoriasis, syndrome X and hypertension were found in 15 patients, diabetes in 7, diabetes and metabolic syndrome in 9 patients, hypertension and metabolic syndrome in 9, hypertension and diabetes in 6 and concomitant concurrent diabetes, metabolic syndrome and hypertension in 14 patients.

Conclusions:
Patients with psoriasis should be given interdisciplinary, comprehensive specialist care due to the increased risk of comorbidity of systemic diseases. The coexistence of systemic diseases in patients with psoriasis, exacerbates existing inflammation. The general practitioner plays a key role in the entire diagnostic and therapeutic process of psoriasis, therefore better understanding of the complex pathomechanisms underlying this dermatosis is necessary, which is the key to effective and safe pharmacotherapy.

REFERENCES (27)

Tsoi L.C., Stuart P.E., Tian C., Gudjonsson J.E, Das S., Zawistowski M., Ellinghaus E., Barker J.N., Chandran V., Dand N., Duffin K.C. i wsp. Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nat. Commun. 2017; 8: 15382, doi: 10.1038/ncomms15382.