Bevacizumab in age-related macular degeneration – comparison of subjective estimation of vision with objective test results
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Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
Private Ophthalmologic Surgery, Katowice, Poland
Clinical Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
Agnieszka Piotrowska-Seweryn
Clinical Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, ul. Francuska 20-24, 40-027 Katowice, tel. +48 696 729 897, e-mail:
Ann. Acad. Med. Siles. 2015;69:33–41
Anti-VEGF therapy plays a great role in medicine, especially in opthalmology. The aim of the therapy is to inhibit the VEGF-A factors that are responsible for the angiogenesis in diseases such as the wet form of age-related macular degeneration (AMD). One of the monoclonal anti-VEGF antibodies is bevacizumab (Avastin®; Genentech, Inc., South San Francisco, CA). The aim of the study was to compare the subjective estimation of visual acuity with objective test results in patients undergoing anti-VEGF therapy using Avastin.

Materials and methods:
The authors report a study of 57 patients (37 females and 20 males) with exudative AMD whose near and distance visual acuity was examined before the first dose of Avastin and 1 month after the third injection. Additionally, an original questionnaire evaluating the subjective state of vision during the activities of daily routine was performed.

When examining distance visual acuity, 29 patients made an improvement, deterioration was reported in 5 cases and in 23 cases the results remained unaltered. The results were correlated with the subjective estimation.

1. Avastin stabilizes the degeneration process of AMD in most patients and sometimes improves visual acuity. 2. There is a positive correlation between the objective test results and subjective opinion in patients undergoing anti-VEGF therapy using Avastin.

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