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Concentrations of chemerin and leptin in healthy and sick newborns
1
Department of Neonatal Intensive Care and Pathology, Faculty of Medical Sciences in Zabrze,
Medical University of Silesia, Katowice, Poland
Corresponding author
Alicja Nawrat
Klinika Intensywnej Terapii i Patologii Noworodka, Wydział Nauk Medycznych w Zabrzu ŚUM, ul. 3 Maja 13, 41-800 Zabrze
Klinika Intensywnej Terapii i Patologii Noworodka, Wydział Nauk Medycznych w Zabrzu ŚUM, ul. 3 Maja 13, 41-800 Zabrze
Ann. Acad. Med. Siles. 2025;79:430-437
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Chemerin and leptin are adipokines involved in the regulation of metabolism and the inflammatory response. In the neonatal period, they may reflect both fetal nutritional status and early adaptive disturbances associated with infection or perinatal risk factors.
Material and methods:
The study included 127 term, appropriate-for-gestational-age newborns, divided into groups: Ia – early-onset infection (n = 40), Ib – perinatal risk factors without infection (n = 36), and II – control group (n = 51). Chemerin and leptin concentrations were measured in peripheral venous blood serum between the 3rd and 7th day of life. Associations between hormonal, metabolic and clinical parameters were analyzed.
Results:
Serum chemerin and leptin concentrations were significantly higher in newborns with early-onset infection and in those burdened with perinatal risk factors compared with healthy infants.
Conclusions:
Chemerin and leptin appear to be markers of metabolic and inflammatory disturbances in the perinatal period. Measurement of their concentrations in peripheral venous blood serum may constitute a valuable adjunctive tool for identifying newborns who require increased clinical surveillance.
Chemerin and leptin are adipokines involved in the regulation of metabolism and the inflammatory response. In the neonatal period, they may reflect both fetal nutritional status and early adaptive disturbances associated with infection or perinatal risk factors.
Material and methods:
The study included 127 term, appropriate-for-gestational-age newborns, divided into groups: Ia – early-onset infection (n = 40), Ib – perinatal risk factors without infection (n = 36), and II – control group (n = 51). Chemerin and leptin concentrations were measured in peripheral venous blood serum between the 3rd and 7th day of life. Associations between hormonal, metabolic and clinical parameters were analyzed.
Results:
Serum chemerin and leptin concentrations were significantly higher in newborns with early-onset infection and in those burdened with perinatal risk factors compared with healthy infants.
Conclusions:
Chemerin and leptin appear to be markers of metabolic and inflammatory disturbances in the perinatal period. Measurement of their concentrations in peripheral venous blood serum may constitute a valuable adjunctive tool for identifying newborns who require increased clinical surveillance.
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