The role of rs1137100 LEPR in pathogenesis of overweight and obesity among study population
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Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
Wladyslaw Jan Grzeszczak   

Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, ul. 3-Maja 13/15, 41-800 Zabrze
Ann. Acad. Med. Siles. 2018;72:141–146
Overweight and obesity have become serious public health problems. They are associated with leptin and the leptin receptor (LEPR). LEPR is one of the gp130 family proteins, which plays a great role in the human body. A number of studies have evaluated many LEPR polymorphisms.

Material and methods:
The study included a group of 510 patients residing in the Upper Silesian Agglomeration (divided into healthy, overweight and obesity groups). The LEPR gene polymorphism was investigated using the Applied Biosystems 7300 Real-Time PCR System. The analysis was carried out with fluorescent-labeled probes by means of ready-to-use assay kits for single nucleotide polymorphism detection.

There were no statistically significant differences in the distribution of genotypes in the healthy and overweight and obese subjects either in the whole group or in the male and female groups (p > 0.05). The incidence of allele A was 76.73% and allele G 23.27%.

There were no significant differences in the distribution of the rs1137100 LEPR polymorphism for the development of overweight and obesity pathogenesis.

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