Evaluation of bone metabolism in obese men and women with metabolic syndrome
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Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, Poland
Department of Health Promotion and Obesity Management, Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland
Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland
Michał Holecki   

Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, ul. Ziołowa 45/47, 40-635 Katowice, Poland, tel.: (0048) 32 359 83 00
Ann. Acad. Med. Siles. 2016;70:133–142
It was suggested that metabolic syndrome (MS) is an additional risk factor that increases the risk of osteoporotic fractures. The aim of this study was to evaluate the impact of metabolic syndrome on bone metabolism and the risk of osteoporotic fracture in obese men and women.

Material and methods:
The study involved 40 obese men and 40 obese women, divided into 2 subgroups: patients without MS (20 men and 20 women); and patients with MS (20 men and 20 women). The serum levels of PTH, 25-OH-D3, CTX1, osteocalcin, FGF23, total Ca and P were determined. The total absolute fracture risk was estimated using the Fracture Risk Assessment Tool. The control group consisted of 15 normal body mass, healthy men and women similar in age.

Obese women with MS have a higher risk of osteoporotic fractures (3.0 vs. 1.6%; p < 0.001) and serum levels of phosphorus (1.8 vs. 1.12 mmol/l; p < 0.001) but lower 25(OH)D3 (7.3 vs. 34.6 ng/ml; p < 0.01) than obese women without MS. There were no differences in the risk of osteoporotic fracture or other study parameters between obese men with and without MS. Women with MS had lower serum CTX1 levels (0.27 ng/ml vs. 0.41 ng/ml; p < 0.05) than men.

Metabolic syndrome does not influence the selected parameters of bone metabolism in either men or women. However, women with metabolic syndrome have lower serum 25-OH-D3 levels. Women, but not men with metabolic syndrome have a higher 10-year absolute fracture risk than obese women with-out metabolic syndrome.

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