Prognostic relevance of hyponatremia after first-ever ischemic stroke
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Department of Neurology, Medical University of Silesia in Katowice, Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland
Department of Internal Medicine and Metabolic Disease, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland
Faculty of Physiotherapy – Institute of Rehabilitation Medicine, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland
Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland
Corresponding author
Michał Holecki   

Department of Internal Medicine and Metabolic Disease, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, ul. Ziołowa 45-47, 40-635 Katowice, Poland, tel. 32 359 82 23
Ann. Acad. Med. Siles. 2016;70:127-132
Hyponatremia is examined as a prognostic factor after first-time ischemic cerebrovascular incident (CVA, ischemic stroke).

Material and methods:
677 patients were analyzed after first-time ischemic stroke and divided into two groups according to sodium concentration: ≤ 135 mmol/L and > 135 mmol/L.

For patients with sodium levels ≤ 135 mmol/L, the median National Institutes of Health Stroke Scale (NIHSS) score was 5 points, the median Modified Rankin Scale (mRS) was 4 points, and the mortality within 1 month of ischemic stroke was 10.5%. Patients with sodium levels > 135 mmol/L: NIHSS 3 points, mRS 2 points and mortality 1 month after ischemic stroke 3.4%. Mortality within 1 month of ischemic stroke in hyponatremic patients: women 16.4%, men 3.5% (p = 0.0194). Greater disability was seen in eunatremic women as assessed by increased mRS scores (p = 0.005).

Hyponatremia is associated with a worsened heath status in patients in the acute and sub-acute phase after first-time ischemic stroke and is associated with increased mortality within 1 month after the stroke. Women with hyponatremia were characterized by greater mortality within one month after their first-ever ischemic stroke. In women with normal serum sodium at the time of stroke, a higher degree of disability was observed as assessed by increased mRS scores compared to men.

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