Assessment of growth retardation in children on renal replacement therapy from 2000 to 2016 – one center experience
 
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1
Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Kraków
 
2
Cardiff and Vale University Health Board, University Hospital of Wales
 
3
Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie
 
 
Corresponding author
Katarzyna Zachwieja   

Department of Pediatric Nephrology, Jagiellonian University Medical College, Kraków, ul. Wielicka 265, 30-663 Kraków
 
 
Ann. Acad. Med. Siles. 2017;71:122-128
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The aim of the study was to assess the growth in children on RRT during the period 2000–2016.

Material and methods:
The diagnosis, comorbidity, RRT data, patient outcome and growth hormone (GH) usage (in 102 patients) and height Z score for 87 patients at the start of RRT and for 94 patients at the end of RRT were analyzed.

Results:
In 60% of patients, peritoneal dialysis was the first method, in 38% hemodialysis and in 2% a preemptive transplantation was performed. The average dialysis time was 34.6 months (1–136 months) and it was statistically longer in the years 2000–2008 than in 2009–2016 (av. 43.3 ± 32.7 months vs 18.3 ± 13.1; p = 0.00005). In the group with comorbidity (46% patients) Z score 0 (start) and Z score 1 (the end) were lower than in the group without comorbidity (average Z score 0: -2.3 ± 2.3 vs -1.08 ± 1.6; p = 0.003) and the dialysis time was also longer (p = 0.02). The Z score in all the patients at the start of RRT was -1.7 ± 2.0 (min: -9.3 to max: +2.0) and there was no statistical dif-ference in comparison to the Z score at the end of RRT: Z score 1; p = 0.37. A Z score < -2.0 was found in 42.5% of children at the start and in 45% at the end of RRT. In 17% of the GH treated group, growth improvement was shown by no difference in Z score 1 in comparison to the group without GH therapy.

Conclusions:
Short stature is still a problem in children on dialysis. Comorbidity is important factor of growth retardation. GH therapy is effective in children on RRT.

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