Introduction:
Lipid metabolism disorders and the obesity connected with them are problems which occur increasingly more frequently in highly-developed countries. Acyl-CoA synthetase (ACSL) is an important enzyme in lipid metabolism taking part in the activation of fatty acids (FA). This makes determining the correlation between the gene polymorphism for ACSL and the development of obesity a relevant research issue.

Aims:
The aim of this study was to examine the dependence of the Acyl-CoA synthetase gene polymorphism on the occurrence of inappropriate body weight and HOMA-IR indicator values.

Material and methods:
A total of 506 patients were examined, whose ACSL5 rs2419621 polymorphism was determined using probes binding with a specific DNA matrix.

Results:
The results of the Hardy-Weinberg equilibrium test showed that the genotype proportions within the population are maintained. Among the patients from the research sample, 177 patients with a proper body weight were identified along with 330 patients with inappropriate Body Mass Index (BMI) values.

Conclusions:
It was determined that there are no differences between the statistical variables in the distribution of acyl-CoA of isoform 5 synthetase gene polymorphism genotypes. Based on the results of the study, a correlation between the gene polymorphism for ACSL5 and the development of obesity cannot be determined.