Polymorphism rs9930506 of FTO gene but fat content in the body of patients who were admitted to the outpatient clinic
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Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach
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Władysław Grzeszczak   

Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach, ul. 3 Maja 13/15, 41-800 Zabrze, tel. +48 32 370 44 14
Ann. Acad. Med. Siles. 2015;69:60-66
The objective of the study was to assess the potential connection between rs 9930506 within the FTO gene and the incidence of obesity and being overweight in a population of people who were admitted to an outpatient clinic.

Materials and methods:
We cumulatively investigated 464 consecutive patients from southern Poland who were admitted to the local outpatient clinic. They were divided into 3 groups (normal, overweight, obese). Genotyping of polymorphism rs 9930506 was performed by using fluorescent marked probes which had been previously prepaired to detect a single nucleotide polymorphism – TaqMan Pre-designed SNP Genotyping Assay (Applied Biosystems).

: In our group the prevalence of being overweight and obese was 72.3%, whence 23.9% constitutes people who were overweight and 48.4% those suffering from obesity. Patients being overweight and obese have a significantly higher blood glucose level than those from the normal group (p < 0.001). The levels of serum insulin in the obese subjects was significantly higher than in the other groups (overweight: p < 0.05, normal: p < 0.001) as well as the levels of overweight people compared to those of a proper weight (p < 0.01). Diabetes was reported in about 13% obese subjects, whereas for people with normative weight was it 2.13%. Subjects being overweight and obese have a significantly higher blood pressure level, higher cholesterol and triglyceride levels and lower eGFR. Our study did not shown any vital correlation between our FTO polymorphism and the prevalence of being overweight or obese. Moreover no significant relationship between rs9930506 FTO and waistline or BMI was found. Finally we proved that the studied polymorphism is connected with the content of adipose tissue in the human body.

Being overweight and obese are connected with many metabolic disorders including carbohydrate and lipid metabolism. We did not find any correlation between rs9930506 and the prevalence of being overweight or obese. Polymorphism rs9930506 was found to be associated with the content of adipose tissue in the human body.

Branca F., Nikogosian H., LobsteinT. The challenge of obesity in the WHO European Region and the strategies for response. WHO Regional Office for Europe, Copenhagen 2007.
Man-Ka Marcella Cheung, Giles S.H. Yeo Why do a billion of us weigh 3 kg more? Lausanne 2011.
Farooqi S., O’Rahilly S. Genetics of obesity in humans. Endocr. Rev. 2006; 27: 710–718.
Comuzzie A., Allison D. The search for human obesity genes. Science 1998; 280: 1374–1377.
Peters T., Ausmeier K., Rüther U. Cloning of Fatso (FTO), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm. Genome 1999; 10: 983–986.
Frayling T., Timpson N., Weedon M. i wsp. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889–894.
Liu C., Mou M., Pan C. The FTO Gene rs9939609 Polymorphism Predicts Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. PLoS One 2013; 8(8): e71901.
Kolackov K., Łaczmański Ł., Bednarek-Tupikowska G. Wpływ polmor-fizmu genu FTO na ryzyko otyłości. Endokrynol. Otył. Zab. Przem. Mat. 2010; 6(2): 101–107.
Fredriksson R., Hagglund M., Olszewski P.K. et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008; 149: 2062–2071, 246–250.
Gerken T., Girard CA., Tung YC. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469–1472.
Choquet H., David Meyre D. Genetics of Obesity: What have we learned? Curr. Genomics. 2011; 12(3): 169–179.
Cecil J., Tavendale R., Watt P. i wsp. An obesity-associated FTO gene variant and increased energy intake in children. N. Engl. J. Med. 2008; 359: 2558–2566.
Wardle J., Carnell S., Haworth C. i wsp. Obesity associated genetic variation in FTO is associated with diminished satiety. J. Clin. Endocrinol. Metab. 2008; 93: 3640–3643.
Müller D., Hinney A., Scherag A. i wsp. Fat mass and obesity associated gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Med. Gen. 2008; 9: 85–90.
Scuteri A., Sanna S., Chen W. i wsp. Genome-Wide Association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: 1200–1210.
Sentinelli F., Incani M., Coccia F. I wsp. Association of FTO polymorphisms with early age of obesity in obese Italian subjects. Exp Diabetes Res. 2012: 872176.
Li H., Wu Y., Loos R.J. I wsp. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 2008; 57(1): 264–268.
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