Pulmonary embolism is a condition in cardiology, constituting direct danger of life, often difficult diagnostically, unpredictable process. It’s characterized by wide spectrum of symptoms, from slightly flagged fatigue, cough, discreet pain in the chest in poorly symptomatic form of no massive disease, to severe dyspnoe, symptoms of a shock through to sudden stop of blood circulation in a massive form. In the article are presented two cases of patients who were admitted to the Otolaryngology Department because of vertigo accompanied by nystagmus as the only one symptom of systemic disorders. During the hospitalization were stated significantly in excess of this accepted norm D-dimer level, which directed further course of diagnostic and therapeutic conduct. Work’s authors have paid attention to very differential disease etiology and the most common risk’s factors. They have described the next stages of diagnostic process from laryngological, audiological opinion to internal and radiological examinations. They have presented and also recommended methods of treatment and have stressed the necessity of management in order to prevent from long lusting disease relapses and meticulous follow up.