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Bombesin-like peptides are able to affect central histamine-induced resuscitating effect in haemorrhage-shocked rats
1
Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
2
Department of Basic Medical Sciences, Faculty of Health Sciences in Bytom, Medical University of Silesia, Katowice, Poland
Corresponding author
Jerzy Jochem
Katedra i Zakład Fizjologii, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, ul. Jordana 19, 41-800 Zabrze
Katedra i Zakład Fizjologii, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, ul. Jordana 19, 41-800 Zabrze
Ann. Acad. Med. Siles. 2020;74:40-45
KEYWORDS
TOPICS
ABSTRACT
Introduction::
Activation of the central histaminergic system induces a resuscitating effect in haemorrhage-shocked rats. Since peripherally administered bombesin evokes a similar action, and bombesin receptors are present in the central nervous system regions responsible for cardiovascular regulation, the aim of the study was to examine the effects of bombesin receptor blockage on histamine-induced cardiovascular effects in haemorrhagic shock.
Material and methods::
Studies were carried out in male Wistar rats anaesthetized with ketamine/xylazine (100 mg/kg + 10 mg/kg, intraperitoneally) and then subjected to reversible haemorrhagic shock with a mean arterial pressure (MAP) of 30–35 mmHg. Immediately after terminating bleeding, the animals were pre-treated intracerebroventricularly (icv) with bombesin receptor antagonists/0.9% NaCl solution, and 5 min later – treated via the same route with histamine (50 nmol) or 0.9% NaCl solution.
Results::
Haemorrhage led to decreases in the pulse pressure (PP), heart rate (HR) and mesenteric blood flow (MBF). Histamine induced a pressor effect, with a significant increase in PP and MBF. The effect was inhibited by both [D-Phe12,Leu14]-bombesin and BIM 23042, non-selective and selective bombesin 1 (BB1) receptor antagonists, respectively. In the control groups the antagonists had no effect.
Conclusions::
Endogenous bombesin-like peptides, acting via BB1 receptors, are able to affect a histamine-induced pressor effect in haemorrhage-shocked rats.
Activation of the central histaminergic system induces a resuscitating effect in haemorrhage-shocked rats. Since peripherally administered bombesin evokes a similar action, and bombesin receptors are present in the central nervous system regions responsible for cardiovascular regulation, the aim of the study was to examine the effects of bombesin receptor blockage on histamine-induced cardiovascular effects in haemorrhagic shock.
Material and methods::
Studies were carried out in male Wistar rats anaesthetized with ketamine/xylazine (100 mg/kg + 10 mg/kg, intraperitoneally) and then subjected to reversible haemorrhagic shock with a mean arterial pressure (MAP) of 30–35 mmHg. Immediately after terminating bleeding, the animals were pre-treated intracerebroventricularly (icv) with bombesin receptor antagonists/0.9% NaCl solution, and 5 min later – treated via the same route with histamine (50 nmol) or 0.9% NaCl solution.
Results::
Haemorrhage led to decreases in the pulse pressure (PP), heart rate (HR) and mesenteric blood flow (MBF). Histamine induced a pressor effect, with a significant increase in PP and MBF. The effect was inhibited by both [D-Phe12,Leu14]-bombesin and BIM 23042, non-selective and selective bombesin 1 (BB1) receptor antagonists, respectively. In the control groups the antagonists had no effect.
Conclusions::
Endogenous bombesin-like peptides, acting via BB1 receptors, are able to affect a histamine-induced pressor effect in haemorrhage-shocked rats.
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