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Effect of prenatal copper exposure on the central dopaminergic system in adult rats
1
Katedra i Zakład Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach
2
Katedra i Zakład Medycyny i Epidemiologii Śląskiego Uniwersytetu Medycznego w Katowicach
3
Wyższa Szkoła Planowania Strategicznego w Dąbrowie Górniczej
Corresponding author
Ryszard Brus
Katedra i Zakład Farmakologii SUM, 41-808 Zabrze, ul. H. Jordana 38, tel./faks +(48 32)272 26 83
Katedra i Zakład Farmakologii SUM, 41-808 Zabrze, ul. H. Jordana 38, tel./faks +(48 32)272 26 83
Ann. Acad. Med. Siles. 2009;63:7-14
KEYWORDS
ABSTRACT
Background:
The eff ect of prenatal exposition of rats with copper on its level in the newborns’ organs and central dopaminergic system activity in adult rats was examined.
Material and Methods:
Pregnant rats during entire time of pregnancy drank water with cupprum sulfuricum (CuSO4) where concentration of metal was 100 ppm. Control rats drank the water only without cuprum. After delivery water with metal was substituted with water only, and newborns stayed with their mothers till 21st day of life, then separated. In newborn copper content was estimated in the brain, liver and kidney. In adult rats the level of biogenic amines was measured in the brain and some behavioral studies were performed such as oral activity, stereotyped and yawning behavior, using central dopamine receptor agonists (SKF 38393, apomorphine, 7-OH-DPAT).
Results and Conclusion:
Exposition of rats during intrauteral development (prenatal) with copper caused significant increase concentration examined metal in the brain, liver and kidney of newborn rats. In adult rats signifi cant decrease of dopamine in the striatum was noticed in the rats pretreated with copper. Beside increase reactivity of the central dopamine D1 receptor reactivity was observed, and manifested by increased oral activity after SKF 38393 and stereotyped behavior after apomorphine apply. Additionally decreased reactivity of the central dopamine D3 receptor was manifested by decreased yawning behavior after 7-OH-DPAT injection. From above we concluded that copper can be one of the environmental agent which can affected of the central dopaminergic system in mammalians
The eff ect of prenatal exposition of rats with copper on its level in the newborns’ organs and central dopaminergic system activity in adult rats was examined.
Material and Methods:
Pregnant rats during entire time of pregnancy drank water with cupprum sulfuricum (CuSO4) where concentration of metal was 100 ppm. Control rats drank the water only without cuprum. After delivery water with metal was substituted with water only, and newborns stayed with their mothers till 21st day of life, then separated. In newborn copper content was estimated in the brain, liver and kidney. In adult rats the level of biogenic amines was measured in the brain and some behavioral studies were performed such as oral activity, stereotyped and yawning behavior, using central dopamine receptor agonists (SKF 38393, apomorphine, 7-OH-DPAT).
Results and Conclusion:
Exposition of rats during intrauteral development (prenatal) with copper caused significant increase concentration examined metal in the brain, liver and kidney of newborn rats. In adult rats signifi cant decrease of dopamine in the striatum was noticed in the rats pretreated with copper. Beside increase reactivity of the central dopamine D1 receptor reactivity was observed, and manifested by increased oral activity after SKF 38393 and stereotyped behavior after apomorphine apply. Additionally decreased reactivity of the central dopamine D3 receptor was manifested by decreased yawning behavior after 7-OH-DPAT injection. From above we concluded that copper can be one of the environmental agent which can affected of the central dopaminergic system in mammalians
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