Malondialdehyde (MDA) – product of lipid peroxidation as marker of homeostasis disorders and aging

Beata Całyniuk; Elżbieta Grochowska-Niedworok; Katarzyna Weronika Walkiewicz; Sylwia Kawecka; Ewa Popiołek; Edyta Fatyga

doi:10.18794/aams/65697

2016 vol. 70

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Malondialdehyde (MDA) – product of lipid peroxidation as marker of homeostasis disorders and aging

Beata Całyniuk ¹

Elżbieta Grochowska-Niedworok ¹

Katarzyna Weronika Walkiewicz ²

Sylwia Kawecka ²

Ewa Popiołek ¹

Edyta Fatyga ²

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Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland

Corresponding author

Katarzyna Weronika Walkiewicz

Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland, ul. Piekarska 18, 41-902 Bytom, tel. 32 281 21 22,

Ann. Acad. Med. Siles. 2016;70:224-228

DOI: https://doi.org/10.18794/aams/65697

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References (44) Citations (51)

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ABSTRACT

Malondialdehyde (MDA) found in the body comes from two sources: food consumed and lipid peroxidation occurring in the tissues. The formation of MDA and the scale and rate of lipid oxidation in the tissues of living organisms is influenced by a number of endo- and exogeneous factors. The products of lipid peroxidation, in particular MDA, exhibit cytotoxic, mutagenic and carcinogenic properties. They can also inhibit enzymes associated with defending cells against oxidative stress. Not only do the occurring processes contribute to the development of many diseases, but they are also a part of the aging process. The body defends itself to some extent against the effects of free radicals by trapping and neutralising them. The main source of antioxidants is food products of plant origin. Lifestyle, the components of which are diet and physical activity, is an important element in preserving health understood as physical and psychological well-being. Dietary habits and a diet rich in antioxidants are modifiable factors which not only prevent age-associated diseases, but also delay aging processes.

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