Dialdehyd malonowy – produkt peroksydacji lipidów jako marker zaburzeń homeostazy i wieku
 
Więcej
Ukryj
1
Department of Human Nutrition, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
2
Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland
AUTOR DO KORESPONDENCJI
Katarzyna Weronika Walkiewicz   

Department of Internal Medicine, School of Public Health in Bytom, Medical University of Silesia in Katowice, Poland, ul. Piekarska 18, 41-902 Bytom, tel. 32 281 21 22,
 
Ann. Acad. Med. Siles. 2016;70:224–228
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Dialdehyd malonowy (MDA) w organizmie człowieka pochodzi z dwóch źródeł: spożywanego pokarmu i peroksydacji lipidów występujących w tkankach. Powstawanie MDA, a także wielkość i szybkość utleniania lipidów w tkankach organizmów żywych, zależy od wielu czynników endo- i egzogennych. Produkty peroksydacji lipidów, szczególnie MDA, wykazują właściwości cytotoksyczne, mutagenne i rakotwórcze. Mogą one również hamować enzymy związane z obroną komórki przed stresem oksydacyjnym. Mogą nie tylko przyczyniać się do rozwoju wielu chorób, ale stanowią również część procesu starzenia się. Organizm broni się w pewnym stopniu przed działaniem wolnych rodników, neutralizując je. Głównym źródłem przeciwutleniaczy jest żywność – produkty pochodzenia roślinnego. Styl życia, na który składają się dieta i aktywność fizyczna, jest ważnym elementem w zachowaniu zdrowia rozumianego jako dobre samopoczucie fizyczne i psychiczne. Nawyki żywieniowe i dieta bogata w przeciwutleniacze są modyfikowalnymi czynnikami, które nie tylko zapobiegają chorobom związanym z wiekiem, ale także opóźniają procesy starzenia.
 
REFERENCJE (44)
1.
Demography Report 2010. Older, more numerous and diverse Euro-peans, European Commission, 2011; www.healthyageing.eu/file resources/ /EUL14135_ Demographyreport_ web.pd.
 
2.
European Commission (DG ECFIN) and Economic Policy Committee (Ageing Working Group). The 2015 Ageing Report. Economic and budgetary projections for the 28 EU Member States 2013–2030. Luxembourg: Publications Office of the European Union, 2015.
 
3.
Harman D. Aging: a theory based on free radicals and radiation che-mistry. J. Gerontol. 1956; 11(3): 288–300.
 
4.
Dmitriev L.F., Titov V.N. Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases. Ageing Res. Rev. 2010; 9(2): 200–210.
 
5.
Niedworok E., Bielaszka A. Comparison of the Effect of Vitamins A and E on Aging Processes of Edible Vegetable Oils. Polish J. of Environ. Stud. 2007; 16(6): 861–865.
 
6.
Marnett L.J, Bienkowski M.J, Raban M., Tuttle M.A. Studies of the hydrolysis of14C-labeled tetraethoxypropane to malondialdehyde. Anal. Biochem. 1979; 99: 458–463.
 
7.
Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress – induced cancer. Chem. Biol. Interact. 2006; 160: 1–40.
 
8.
Marnett L.J. Oxy radicals, lipid peroxidation and DNA damage. Toxicol 2002; 181–182: 219–222.
 
9.
Blair I.A. Lipid hydroperoxide-mediated DNA damage. Exp. Gerontol. 2001; 36: 1473–1481.
 
10.
Niederhofer L.J., Daniels J.S., Rouzer C.A., Greene R.E., Marnett L.J. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J. Biol. Chem. 2003; 278(33): 31426–31433.
 
11.
Chen J.I., Petersen D.R., Schenker S., Henderson G.I. Formation of malondialdehyde adducts in livers of rats exposed to ethanol: role in ethanol-mediated inhibition of cytochrome c oxidase. Alcohol Clin. Exp. Res. 2000; 24(4): 544–552.
 
12.
Casado A., Encarnación López-Fernández M., Concepción Casado M., de La Torre R. Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem Res. 2008; 33(3): 450–458.
 
13.
Siu G.M., Draper H.H. Metabolism of malonaldehyde in vivo and in vitro. Lipids 1982; 17(5): 349–355.
 
14.
Raghavan S., Subramaniyam G., Shanmugam N. Proinflammatory effects of malondialdehyde in lymphocytes. J. Leukoc. Biol. 2012; 92(5): 1055–1067.
 
15.
Yang I.Y., Chan G., Miller H., Huang Y., Torres M.C., Johnson F., Moriya M. Mutagenesis by acrolein-derived propane deoxyguanosine adducts in human cells. Biochemistry 2002; 41: 13826–13832.
 
16.
De Bont R., Van Larebeke N. Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis 2004; 19: 169–185.
 
17.
Veneskoski M., Turunen S.P., Kummu O., Nissinen A., Rnnikko S., Levonen A.L., Hörkkö S. Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a. Free Radical Biol. Med. 2011; 51(4): 834–843.
 
18.
Rani V., Yadav U.C. Free radicals in Human Health and Diseases. Springer. India 2015.
 
19.
Gil L., Siems W., Mazurek B., Gross J., Schroeder P., Voss P., Grune T. Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes. Free Radic. Res. 2006; 40: 495–505.
 
20.
Suresh D.R., Sendil K., Annam V., Hamasaveena Age related changes in malondialdehyde: total antioxidant capacity ratio- a novel marker of oxidative stress. Int. J. Pharm. Bio. Sci. 2010; 1(2): 1–6.
 
21.
Jha R., Rizvi S.I. Carbonyl formation in erythrocyte membrane proteins during aging in humans. Biomed Pap. Med. Fac. Univ. Palacky Olomunc 2011; 155(1): 39–42.
 
22.
Mahla V.K., Mahla M., Gupta R.C., Rawtani J. A study to evaluate the effect of menopause on oxidative stress. International Journal of Physiology 2014; 2(1): 118–123.
 
23.
Casado A., Encarnación López-Fernández M., Concepción Casado M., de La Torre R. Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem. Res. 2008; 33(3): 450–458.
 
24.
Dzięgielewska-Gęsiak S., Wysocka E., Michalak S., Nowakowska-Zaj-del E., Kokot T., Muc-Wierzgoń M. Role of lipid peroxidation products, plasma total antioxidant atatus, and Cu-, Zn-superoxide dismutase activity as biomarkers of oxidative stress in elderly prediabetics. Oxid. Med. Cell. Longev 2014; 2014: ID987303, p. 1–8.
 
25.
Karolkiewicz J. Effects of oxidative stress and free-radical mediated damage on cell structure and function – connection to aging process. Ge-rontol. Pol. 2011; 19(2): 59–67.
 
26.
Klaunig J., Kamendulis L., Hocevar B. Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol. 2010; 38(1): 96–109.
 
27.
Sosa V., Moliné T., Somoza R. Paciucci R., Kondoh H., Lleonart M.E. Oxidative stress and cancer: An overview Ageing Res. Rev. 2013; 12: 376–390.
 
28.
Parše M. Oxidative stress in the pathogenesis of colorectal cancer: cause or consequence? Biomed Res. Int. 2013; ID 725710.
 
29.
Gönenç A., Ozkan Y., Torun M., Simşek B. Plasma malondialdehyde (MDA) levels in breast and lung cancer patients. J. Clin. Pharm. Therap. 2001; 26(2): 141–144.
 
30.
Aznar J., Santos M.T., Valles J., Sala J. Serum malondialdehyde-like material (MDA-LM) in acute myocardial infarction. J. Clin. Pathol. 1983; 36: 712–715.
 
31.
Lee R., Margaritis N., Channon K.M., Antoniades C. Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations. Curr. Med. Chem. 2012; 19(16): 2504–2520.
 
32.
Antoniades C., Antonopoulos A.S., Bendall J.K., Channon K.M. Targeting redox signaling in the vascular wall: from basic science to clinical practice. Curr. Pharm. Des. 2009; 15: 329–342.
 
33.
Walter M.F., Jacob R.F., Bjork R.E., Jeffers B., Buch J., Mizuno Y., Mason R.P. Circulating lipid hydroperoxides predict cardiovascular events in patients with stable coronary artery disease: the PREVENT study. J. Am. Coll. Cardiol. 2008; 51(12 ): 1196–1202.
 
34.
Li G., Chen Y., Hu H., Liu L., Hu X., Wang J., Shi W., Yin D. Association between age-related decline of kidney function and plasma malondiadehyde. Rejuvenation Res. 2012; 15(3): 257–264.
 
35.
Ostalowska A., Koczy B., Słowińska L., Kasperczyk A. Oxidative stress and enzymatic antioxidant status of blood and synovial fluid in rheumatoid arthritis patients. Ann. Acad. Med. Siles. 2016; 70: 196–205.
 
36.
Wiktorowska-Owczarek A., Nowak J.Z. Pathogenesis and prophylaxis of AMD: focus on oxidative stress and antioxidants. Postepy Hig. Med. Dosw. 2010; 64: 333–343.
 
37.
Wang H., Zhao B., Vrcek I., Johnston J.M. Role of Malondialdehyde in the Age-Related Macular Degeneration. In: Oxidative Stress in Applied Basic Research and Clinical Practice. Ed. Sttraton et al. Springer Science + Business Media. LLC 2012, s. 85–93.
 
38.
Ates O., Azizi S., Alp H.H., Kiziltunc A., Beydemir S., Cinici E., Kocer I., Baykal O. Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. Tohoku J. Exp. Med. 2009; 217: 17–22.
 
39.
Gutowicz M. The influence of reactive oxygen species on the central nervous system. Postepy Hig. Med. Dosw. 2011; 65: 104–113.
 
40.
Andersen J.K. Oxidative stress in neurodegeneration: cause or con-sequence? Nat. Med. 2004; 10 Suppl: S18–28.
 
41.
Hensley K., Maidt M.L., Sang H., Markesbery W.R., Floyd R.A. Ele-ctrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J. Neurosci. 1998; 18, 8126–8132.
 
42.
Bulut M., Selek S., Gergerlioglu S., Savas H.A., Yilmaz R.H., Yuce M., Ekici G. Malondialdehyde levels in adult attention-deficit hyperactivity disorder. J. Psychiatry Neurosci. 2007; 32(6): 435–438.
 
43.
MeiLian T., NingNing X., Ming Fang Y., JinFeng Ch., XingChu Y. Effects of sunflower artificial aging on seed vigor and physiological characteristics. Agricultural Sci Tech. 2010; 11(4): 39–43.
 
44.
Pamplona R., Barja G. Mitochorndrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim. Biophys. Acta. 2006; 1757: 496–508.
 
 
CYTOWANIA (15):
1.
Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice
Bo Ren, Tian Yuan, Xinglin Zhang, Luanfeng Wang, Junru Pan, Yan Liu, Beita Zhao, Weiyang Zhao, Zhigang Liu, Xuebo Liu
Journal of Agricultural and Food Chemistry
 
2.
Evaluation of the effect of thymoquinone in d ‐galactose‐induced memory impairments in rats: Role of MAPK , oxidative stress, and neuroinflammation pathways and telomere length
Zahra Oskouei, Soghra Mehri, Fatemeh Kalalinia, Hossein Hosseinzadeh
Phytotherapy Research
 
3.
Exposure to per- and polyfluoroalkyl substances and premature skin aging
Sayed Mousavi, Juana Delgado-Saborit, Lode Godderis
Journal of Hazardous Materials
 
4.
Cu(II) Complexes with FomA Protein Fragments of Fusobacterium Nucleatum Increase Oxidative Stress and Malondialdehyde Level
Monika Lesiów, Piotr Pietrzyk, Agnieszka Kyzioł, Urszula Komarnicka
Chemical Research in Toxicology
 
5.
Synergistic effects of Ficus Carica extract and extra virgin olive oil against oxidative injury, cytokine liberation, and inflammation mediated by 5-Fluorouracil in cardiac and renal tissues of male albino rats
Mona Elghareeb, Gehad Elshopakey, Basma Hendam, Shaymaa Rezk, Samah Lashen
Environmental Science and Pollution Research
 
6.
Inhibitory Effects of Selenium on Arsenic-Induced Anxiety-/Depression-Like Behavior and Memory Impairment
Noreen Samad, Tazeen Rao, Muhammad Rehman, Sheraz Bhatti, Imran Imran
Biological Trace Element Research
 
7.
Evaluation of the Low Inclusion of Full-Fatted Hermetia illucens Larvae Meal for Layer Chickens: Growth Performance, Nutrient Digestibility, and Gut Health
Xiaohua Chu, Mengmeng Li, Guiying Wang, Kuiming Wang, Rongsheng Shang, Ziyu Wang, Lusheng Li
Frontiers in Veterinary Science
 
8.
Pro-Oxidant Enzymes, Redox Balance and Oxidative Damage to Proteins, Lipids and DNA in Colorectal Cancer Tissue. Is Oxidative Stress Dependent on Tumour Budding and Inflammatory Infiltration?
Justyna Zińczuk, Mateusz Maciejczyk, Konrad Zaręba, Anna Pryczynicz, Violetta Dymicka-Piekarska, Joanna Kamińska, Olga Koper-Lenkiewicz, Joanna Matowicka-Karna, Bogusław Kędra, Anna Zalewska, Katarzyna Guzińska-Ustymowicz
Cancers
 
9.
ROS-mediated lipid peroxidation as a result of Cu(ii) interaction with FomA protein fragments of F. nucleatum: relevance to colorectal carcinogenesis
Monika Lesiów, Urszula Komarnicka, Agnieszka Kyzioł, Alina Bieńko, Piotr Pietrzyk
Metallomics
 
10.
AST/ALT levels, MDA, and liver histopathology of Echinometra mathaei ethanol extract on paracetamol-induced hepatotoxicity in rats
Angelica Kresnamurti, Dita Rakhma, Amitasari Damayanti, Septiyan Santoso, Enggar Restryarto, Wifqi Hadinata, Iwan Hamid
Journal of Basic and Clinical Physiology and Pharmacology
 
11.
Protective effect of gallic acid against arsenic-induced anxiety−/depression- like behaviors and memory impairment in male rats
Noreen Samad, Sadia Jabeen, Imran Imran, Iqra Zulfiqar, Kainat Bilal
Metabolic Brain Disease
 
12.
Effects of Essential Trace Elements and Oxidative Stress on Endemic Arsenism Caused by Coal Burning in PR China
Yong Hu, Tingting Xiao, Qi Wang, Bing Liang, Aihua Zhang
Biological Trace Element Research
 
13.
The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats
Yong Hu, Chun Yu, Maolin Yao, Lei Wang, Bing Liang, Bixia Zhang, Xiaoxin Huang, Aihua Zhang
Environmental Toxicology and Pharmacology
 
14.
Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice
Noreen Samad, Natasha Manzoor, Zahra Muneer, Sheraz Bhatti, Imran Imran
Metabolic Brain Disease
 
15.
Malondialdehyde (MDA) Production in Atherosclerosis Supplemented with Steamed Tomato
Iswari Sri, Muchamad Dafip, Eling Purwantoyo
Pakistan Journal of Biological Sciences
 
eISSN:1734-025X