Introduction:
Osteoporosis is a skeletal disturbance in which bone endurance is at increased risk of fracture. It was demonstrated that genetic variations in RANK are associated with skeletal diseases.

Materials and methods:
The aim of the study is to examine the frequency of RANK gene polymorphism and evaluation of its relation with clinical parameters concerning bone turnover and the degree of postmenopausal osteoporosis progress.

Results:
The obtained results did not show correlation of RANK C575T polymorphism with decreased bone density and increased risk of postemopausal osteoporosis incidence.

Conclusions:
Homozygote of TT polymorphism of RANK receptor gene isn't an increased risk factor of osteoporosis development and is associated with lower values describing bone density in women with osteoporosis and osteopenia.