Introduction:
TCF7L2 is linked with pathogenesis of insulin - resistant diabetes. The participation of the polymorphism of the gene, which encodes TCF7L2 in development of overweight and obesity is still controversial. The estimate of possible association between the chosen polymorphism of TCF7L2 and prevalence of overweight and obesity in population of patients reporting to the primary healthcare clinic.

Materials and methods:
476 patients (208 men and 268 women) from the southern Poland, which reported to the primary healthcare clinic, were examined. They were divided in three groups, depended on girth. In genotyping of polymorphism TCF7L2 (rs 7903146) there were used fluorescent probes from prepared set for assaying of single nucleotide polymorphism: TaqMan Pre-designed SNP Genotypie Assai (Applied Biosystems).

Results:
The overweight was found out at 23,9% and the abdominal obesity was certified at 47,1% of patients. Our study did not show any significant correlation between observed polymorphism rs 7903146 of TCF7L2 gene and prevalence of overweight and obesity. However it was not found any significant relationship between polymorphism rs 7903146 of TCF7L2 gene and waistline or BMI.

Conclusions:
The prevalence rate of obesity and overweight in examined group amounted to 72,3% (23,9% - overweight and 48,4% - obesity). Preliminary tests did not certify association between the chosen polymorphism rs 7903146 of TCF7L2 gene and prevalence of overweight and abdominal obesity.