Cardiovascular disease (CVD) is a leading cause of death worldwide. Only in 2012 it accounted for 17.5 million deaths. Although it affects both sexes, every year more women die due to CVD, more than due to all cancers, tuberculosis, HIV/AIDS and malaria combined. The risk factors, symptoms and course of CVD in women and men often differ, which makes early proper diagnosis and treatment more difficult. Despite being a major threat for women, the level of awareness and knowledge on the gender- -specific picture of CVD, both among females and within the medical environment, remains staggeringly low. Introducing a new gender-tailored health education and prevention model, adjusted to the medical, socio-cultural, technological expectations and needs of contemporary women, to their modern lifestyle and pace of life, could constitute an attractive and more effective alternative to initiatives undertaken so far targeting the general population. E- and m-health tools seem to have a promising potential in educating and supporting contemporary women in their everyday health management. Applying Internet-based solutions together with a gender-oriented approach could increase the level of knowledge and CVD awareness among women, lead to improvement of their heart health and contribute to a reduction in the medical-social-economic burden of CVD in women.