Introduction:
Natrium butyrate is a chemical compound which seems to have several beneficial properties, which alleviate signs and symptoms of gastrointestinal diseases. As a result, it has become a frequent component of therapeutic regimens. However, all of the oral products containing natrium butyrate available on the Polish market are registered as dietary supplements and none of them is approved for use as a medication, which might raise concerns about their quality.

Material and methods:
Natrium butyrate from eight different dietary supplements available on the Polish market in April 2024 was extracted with diethyl ether. Subsequently, diethyl ether was evaporated and remnants were dissolved in methanol in order to perform high performance liquid chromatography (HPLC). Obtained solutions were passed through a chromatography column to assess exact content of natrium butyrate in each sample. Finally, obtained peaks were compared with standard samples and the content of natrium butyrate in each sample was calculated.

Results:
Sodium butyrate content was detected in each of the analyzed samples. However, the percentage ratio of the amount detected to that declared by the producers varied from 45.51% to 106.15%.

Conclusions:
In the majority of cases, analyzed dietary supplements contained natrium butyrate in quantities similar to those declared by manufacturers; however, compliance with the manufacturer's declaration varied between specific products, highlighting the need for further research in this area.