Introduction:
In patients with heart failure (HF), left ventricular remodeling can lead to secondary mitral regurgitation (SMR), which exacerbates HF symptoms and reduces quality of life (QoL). Transcatheter edge-to-edge repair (TEER), an interventional therapy for patients with SMR and high surgical risk, allows effective reduction of mitral regurgitation, leading to improved survival and quality of life. However, data on QoL outcomes post-TEER in the Polish population remain limited.

Material and methods:
Aim of the study was to assess changes in QoL, measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ-12), in patients with severe SMR undergoing TEER. This prospective, single-center, observational study included 42 consecutive patients with severe SMR who underwent TEER. Main outcome was QoL change after 3 months.

Results:
TEER was performed successfully in all cases without any major complications. An improvement in KCCQ-12 was observed in 38/42 (90.5%) of patients, mean KCCQ-12 score before and after 3-month was 41.9 ± 15.5 vs 61.4 ± 16.9, respectively (p < 0.001). The most significant improvement was observed among patients with lower initial QoL (r = -0.462; p = 0.002) and among patients without co-existing severe tricuspid regurgitation (Δ +21.7 vs +5.5; p = 0.04). During the follow-up period, only one patient required unplanned hospitalization.

Conclusions:
TEER is associated with a significant improvement in QoL at 3-month follow-up in patients with severe SMR. These findings support TEER as a valuable treatment strategy, providing important data for clinical practice in Poland.