Impact of selected pro-inflammatory cytokines and oxidative stress on carcinogenesis and progression of prostate and colorectal adenocarcinomas
 
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1
Oddział Urologii, Szpital „GeoMedical”, Katowice
 
2
Katedra i Zakład Biochemii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
 
3
Centrum Medyczne „Antrum”, Laboratorium „Demeter”, Bytom
 
4
Niepubliczny Zakład Opieki Zdrowotnej, Szpital „Jakubiec”, Myszków
 
5
Katedra Pielęgniarstwa, Wyższa Szkoła Zarządzania w Częstochowie
 
 
Corresponding author
Michal Fryczkowski   

Oddział Urologii, Szpital „GeoMedical”, ul. Wita Stwosza 41, 40-042 Katowice
 
 
Ann. Acad. Med. Siles. 2019;73:182-193
 
KEYWORDS
TOPICS
ABSTRACT
Colorectal and prostate cancers have one of highest occurrence rate in Poland and the incidence is constantly increasing. Chronic inflammation and oxidative stress are known factors that promotes the development of cancer. Pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α are produced in normal cells and are responsible for controlling key processes. However overproduction associated with chronic inflammation may induce tumor transformation and suport tumor growth by expression of cytokines by tumor microenvironment cells. The concentration of pro-inflammatory cytokines in the serum and expression in tumor tissue may be a diagnostic and prognostic factor for patients with colorectal or prostate cancer, and anti-cytokine therapy may increase patients survival.
 
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