The relationship between body mass index, waist circumference and glomerular filtration rate in young men
 
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Katedra i Klinika Chorób Wewnętrznych i Metabolicznych Śląskiego Uniwersytetu Medycznego w Katowicach
 
 
Corresponding author
Anna Hawrot-Kawecka   

Klinika Chorób Wewnętrznych i Metabolicznych Katedra Chorób Wewnętrznych Wydział Opieki Zdrowotnej Śląskiego Uniwersytetu Medycznego, ul. Ziołowa 45/47, 40-635 Katowice, tel./fax +48 32 359 82 99
 
 
Ann. Acad. Med. Siles. 2010;64:31-35
 
KEYWORDS
ABSTRACT
Introduction:
The aim of this study was to answer the question what the dependence of glomerular filtration rate from the body mass index and waist circumference is.

Material and Methods:
The study included 48 men aged 18–30, 19 of which (40%) had normal weight, 15 (31%) – were overweight, and 14 (29%) were obese (n = 14). 25 men (52%) had waist circumference less than 94 cm, 8 men (16%) in the range 94-102 cm, and 15 (32%) had greater than 102 cm. Their height, weight, waist circumference, serum creatinine, BMI, were measured using GRF MDRD equations and Cockcroft-Gault equation.

Results:
GFR estimated by the Cockcroft-Gault equation in men with normal body weight was 124.5 ml / min ± 19.5 ml / min, with overweight – 156.7 ml / min ± 29.3 ml / min, with obesity – 215.1 ml / min ± 61.6 ml / min. GFR estimated by MDRD equation was: 107.5 ml / min ± 13.5 ml /min, 112.4 mL / min ± 17.4 ml / min, 115.1 mL / min ± 21.0 ml / min. GFR estimated by the Cockcroft-Gault equation in men with waist circumference < 94cm was 126.4 ml / min ± 18.7 ml / min, with waist circumference 94-102 cm – 169.3 ml / min ± 20.2 ml / min and with waist circumference> 102 cm - 214.2 ml / min ± 60.2 ml / min. GFR estimated by MDRD formula respectively was 106.4 ml / min ± 13.4 ml / min, 119.5 mL / min ± 13.5 ml / min, 114.8 mL / min ± 22.1 ml / min. Signifi cant diff erences between groups occurred only after application of the Cockcroft-Gault equation.

Conclusions:
The results of this study support the assertion that the MDRD formula is more credible than the Cockcroft-Gault equation to assess renal function in patients with overweight and obesity, including abdominal obesity.

 
REFERENCES (3)
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Levey A.S. Coresh J., Greene T. Using Standardized Serum Creatinine Values in the Modifi cation of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate. Ann. Intern. Med. 2006 Aug 15;145(4):247.
 
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Kallner A., Ayling P.A., Khatami Z. Does eGFR improve the diagnostic capability of S-Creatinine concentration results? A retrospective population based study. Int. J. Med. Sci. 2008 Jan 5;5(1):9.
 
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