PL EN
 
5/2009 vol. 63
Pobierz cytowanie
Carrier-state of the A allele of – 455G>A polymorphism within the beta fibrinogen gene increases the risk of coronary artery disease in the presence of elevated concentration of serum triacylglycerols
Beata Sarecka-Hujar 1
,
 
Iwona Zak 1
,
 
Jolanta Krauze 2
 
 
 
Więcej
Ukryj
1
Department of Biochemistry and Medical Genetics, School of Health Care, Medical University of Silesia, Katowice, Poland
 
2
The First Department of Cardiac Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
 
 
Autor do korespondencji
Beata Sarecka-Hujar   

Department of Biochemistry and Medical Genetics, School of Health Care Medical University of Silesia, Kasztanowa Str. 3, 41-200 Sosnowiec, Poland; phone: (+48 32) 269 98 20
 
 
Ann. Acad. Med. Siles. 2009;63:41-49
 
Artykuł (PDF)
Referencje (36)
 
SŁOWA KLUCZOWE
choroba wieńcowa
polimorfi zm
fi brynogen beta
lipidy
tradycyjne czynniki ryzyka
 
STRESZCZENIE
Wstęp:
Fibrynogen promuje rozwój zmian miażdżycowych przez przyleganie do zmienionej ściany tętnic gdzie jest przekształcany w fi brynę. Celem niniejszej pracy była ocena związku między polimorfi zmem –455G>A genu kodującego łańcuch beta fi brynogenu (FGB) a ryzykiem choroby wieńcowej (CAD, ang. coronary artery disease) w grupie pacjentów z Górnego Śląska i ustalenie czy istnieją interakcje między tym polimorfi zmem a tradycyjnymi czynnikami ryzyka miażdżycy w determinowaniu ryzyka CAD.

Materiał i metody:
Grupę badaną stanowiło: 191 pacjentów z potwierdzoną koronarograficznie CAD oraz 203 krwiodawców bez obciążeń chorobami sercowo-naczyniowymi. Polimorfizm –455G>A genu FGB genotypowano metodą RFLP-PCR. Wyniki. Częstości genotypów polimorfizmu -455G>A genu FGB były zgodne z równowagą Hardy-Weinberg’a. Nie stwierdzono znamiennych różnic w częstości allela A i nosicieli allela A polimorfizmu genu FGB między pacjentami a grupą kontrolną. Obserwowano tendencję do występowania wyższego poziomu fi brynogenu w osoczu osób z genotypami AA i GA w porównaniu do poziomu fi brynogenu w osoczu osób z genotypem GG. Stwierdzono również silny synergiczny efekt między nosicielstwem allela A a podwyższonym poziomem triglicerydów w determinowaniu ryzyka CAD (indeksy synergii SI=5.97, SIM=2.63). Nosiciele allela A charakteryzujący się podwyższonym poziomem triglicerydów występowali trzykrotnie częściej w grupie chorych niż w kontroli (12.0% vs 3.9%, p=0.003,OR=3.34).

Wyniki:
Przedstawione wyniki wskazują na synergiczny związek nosicielstwa allela A polimorfizmu – 455G>A genu FGB z ponadnormatywnym stężeniem triglicerydów w surowicy krwi w kształtowaniu ryzyka CAD w populacji pacjentów z Górnego Śląska.

ISSN 0208-5607
 
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