Stres oksydacyjny i enzymatyczny układ entyoksydacyjny we krwi i płynie stawowym pacjentów z reumatoidalnym zapaleniem stawów
 
Więcej
Ukryj
1
Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice
2
Department of Orthopaedics, District Orthopaedic Hospital, Bytom
3
Department of Biophysics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice
AUTOR DO KORESPONDENCJI
Alina Beata Ostałowska   

MD, PhD, Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, tel. +48 32 272 23 18
 
Ann. Acad. Med. Siles. 2016;70:196–205
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Wstęp:
W patogenezie reumatoidalnego zapalenia stawów jednym z mechanizmów uszkadzających struktury stawu są reakcje z udziałem reaktywnych form tlenu (RFT).

Materiał i metody:
U 178 pacjentów z RZS oraz 27 zdrowych ochotników oznaczono we krwi i płynie stawowym aktywność enzymów antyoksydacyjnych: izoenzymów dysmutazy ponadtlenkowej manganowej (MnSOD) i cynkowo--miedziowej (CuZnSOD), katalazy (CAT), peroksydazy glutationowej (GPX), reduktazy glutationowej (GR) i transferazy-S-glutationowej (GST) oraz stężenie dialdehydu malonowego (MDA).

Wyniki:
We krwi i płynie stawowym pacjentów z RZS dochodzi do pobudzenia układu antyoksydacyjnego ze wzrostem aktywności enzymów antyoksydacyjnych, zwiększonym stężeniem MDA oraz spadkiem lepkości płynu stawowego.

Wnioski:
Zależność między nasileniem zmian w układzie antyoksydacyjnym a aktywnością zapalenia stawów po-twierdza udział RFT w patogenezie i przebiegu RZS.

 
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CYTOWANIA (1):
1.
Malondialdehyde (MDA) – product of lipid peroxidation as marker of homeostasis disorders and aging
Beata Całyniuk, Elżbieta Grochowska-Niedworok, Katarzyna Walkiewicz, Sylwia Kawecka, Ewa Popiołek, Edyta Fatyga
Annales Academiae Medicae Silesiensis
 
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